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Cagrilintide alone produced about 11.8% weight loss at 68 weeks in monotherapy and roughly 20.4% combined with semaglutide in REDEFINE-1

Graphical Abstract Keywords Insulin resistance, Lipid metabolism, Metabolic dysfunction-associated steatotic liver disease, MASLD, Oxidative stress, Silent information regulator 1, SIRT1, Therapeutic targeting Introduction Metabolic dysfunction-associated steatotic liver disease (MASLD) is a prevalent chronic liver condition closely linked to metabolic abnormalities