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2021;24(3) Zhou XJ, et al

The first mechanism centers on the production of reactive oxygen species (ROS) and reactive nitrogen species (RNS), leading to biomolecular oxidation, consequentially resulting in cellular dysfunction and mortality

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The promising effects observed in vitro often require sophisticated formulations (e.g., with piperine, nanoparticles) to be partially translated in humans, raising questions about the efficacy of simple dietary intake or standard extracts (50)

Furthermore, TFR2 regulated the cell cycle of colon cancer cells utilizing the ERK pathway (39)