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Acknowledgments We are grateful to the patients and clinical staff (Xiaojing Dong, Xingwei Jiang, Xiaolin Gan, and Xiaojiao Li) from the department of obstetrics and gynecology department (The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China) for their generous contributions to this study

Furthermore, metformin treatment significantly decreased IL-1 level but had no significant effect on IL-6 in the plasma of Nrf2 KO mice under OA condition (Fig

Krentz, A