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These findings align with previous studies showing that GPX4 undergoes a rapid decline in IIRI models, suggesting that lipid peroxides eventually impair GPX4 expression [8]

Interestingly, repeated NFT treatment resulted in higher GCLC levels in the days after removal of the compound and an elevated induction in response to a second exposure to NFT, similar to the previously published pattern of sulfiredoxin synthesis upon repeated exposure to DEM or tert -butylhydroquinone (Bischoff et al

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Haahtela T, Holgate S, Pawankar R, Akdis CA, Benjaponpitak S, Caraballo L, Demain J, Portnoy J, von Hertzen L, WAO Special Committee on Climate Change and Biodiversity