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These findings suggest that GLP-1 and its metabolites might modulate TRPV1 activity, which plays a pivotal role in heat pain perception 19,49

This means that for every 100 people using semaglutide, fewer than five might experience leg cramps

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Moreover, exaggerated inflammatory disorders in Covid-19 due to the release of pro-inflammatory cytokines like IL-1, IL-6, and TNF- may lead to the development of systemic inflammation and cytokine storm (Zanza et al

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