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150 With this understanding, many pharmaceutical researchers have conjugated their bioactive compounds to lipophilic moieties in the hope that they will become sufficiently lipid soluble to passively move through the BBB

263,272 Considerations in women Women of reproductive age taking a GLP-1 receptor agonist or tirzepatide should be advised to use contraception concurrently due to potential safety concerns associated with taking these pharmacotherapies in pregnancy (as shown in animal studies)

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