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The FDA regulation requires any patient with a BMI over 30 or a BMI of 27 or more if they have a health-related obesity issue, including but not limited to high blood pressure, insulin resistance, sleep apnea or high cholesterol
At the end of its 2 year shelf life, when stored in the refrigerator, there are approximately 350 mg
Overall, this evidence suggests that abnormally high or low levels of estradiol can both lead increased insulin resistance in the brain and peripheral tissues
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