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The mechanism is purely metabolic: increased energy expenditure , suppressed lipogenesis, and elevated NAD+ levels that activate sirtuins (SIRT1, SIRT3), the same longevity-associated enzymes targeted by caloric restriction

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Puapatanakul P, Miner JH

The Effect of Exenatide Once Weekly on Carotid Atherosclerosis in Individuals With Type 2 Diabetes: An 18-Month Randomized Placebo-Controlled Study