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In the short-term, however, the paper emphasizes the importance of nailing down just how metabolites within different compartments operate within our cells

4.4 Neuronal inflammatory response Under peripheral inflammatory conditions, the continuous release of inflammatory mediators may result in sustained activation of the neuronal inflammatory response, causing direct damage to neurons (Vasunilashorn et al., 2021)

When your cells can't process environmental and metabolic demands efficiently, simply avoiding triggers or adding isolated supplements doesn't restore the underlying processing capacity