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Release kinetic analysis The mechanism of drug release was evaluated by fitting data to various kinetic models: zero-order, first-order, Higuchi diffusion, and KorsmeyerPeppas equation 38

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The cellular complexity-related features of apoptosis: involvement of organelles Apoptosis is a caspase-dependent RCD which was first described in 1972 based on a characteristic cellular morphology such as cell shrinkage, nuclear condensation, formation of apoptotic bodies, etc [71, 72]