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The fatigue typically stems from three sources: reduced caloric intake (you are eating less, which means less fuel), GI discomfort (nausea and stomach issues are exhausting), and metabolic adjustment as your body adapts to new hormone signaling patterns

separate them by time of day or by minutes if layering

And obesity can come with all kinds of downstream health effects like high blood pressure and heart disease

Ghazarian M, Revelo XS, Nhr MK, Luck H, Zeng K, Lei H et al