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Patients carrying specific genetic profiles may show superior outcomes with tirzepatide (a dual GLP-1/GIP receptor agonist) rather than semaglutide alone

MCA205 cells were transfected with pcDNA3.1(+)-IL18R1-EGFP-StrepII and pcDNA3.1(+)-CXCL10-TagRFP-Flag for IP

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This not only minimizes mitochondrial oxygen consumption under hypoxia but also limits the generation of mitochondrial ROSa byproduct of electron leakage from the electron transport chain (ETC) (80)