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doi:10.1111/ijd.17934 Patil S, Mitra D

& Pasquale, E

3.6 Switching from dulaglutide to semaglutide 3.6.1 Study characteristics In this part of our investigation, we thoroughly examined three studies centered on the transition from Dulaglutide to Semaglutide

This gradual escalation prevents overwhelming side effects like flushing, nausea, or headaches that occur when starting at high doses, allows the pituitary to adapt to regular stimulation improving long-term response, and provides opportunity to identify minimal effective dose avoiding unnecessary higher dosing and associated costs

Third, although protective effects were observed in preclinical models, their applicability to human OA remains uncertain, and well-designed clinical trials are necessary to validate these findings