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Research has revealed a notable imbalance in T cell subsets in RA patients' peripheral blood and synovium, which is typified by higher percentages of Th1 and Th17 cells and an overabundance of inflammatory cytokines (such IL-17, TNF-, IL-23, IL-1, etc.) (133135)

Vitamins of group B assist in the inflammatory processes, lymphocyte proliferations and their deficiency can significantly affect the immune system response (Arruda de Souza Monnerat et al

The macromolecular receptor was processed using AutoDockTools 1.5.7 software, including the addition of hydrogen bonds, calculation of charges, setting of rigid structures, and designation as the receptor, and then exported in PDBQT format

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