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The global increase in the prevalence of CKD is linked to the increasing prevalence of traditional risk factors, including obesity, hypertension, and diabetes mellitus, as well as metabolic factors, particularly insulin resistance, dyslipidemia, and hyperuricemia

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Immunofluorescence results showed a significant increase in FOXO4 and p53bp1 foci within the nucleus of senescent cells compared to those in dividing cells (Figure

Groups at higher risk include older adults, people with kidney disease, people with autoimmune conditions, heavy alcohol consumers, and people taking certain medications that deplete B6 stores (including some oral contraceptives and isoniazid)