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Kawamura T, Ogawa Y, Nakamura Y, Nakamizo S, Ohta Y, Nakano H, et al

Read the evidence A 2017 meta-analysis (N = 1,211) found that in patients with hyperuricaemia and CKD, urate-lowering treatment slowed renal function decline, limited proteinuria and reduced the relative risk of cardiovascular events or renal failure by over 50% 12 A 2020 meta-analysis (N = 6,458) found that urate-lowering treatment did not significantly reduce the risk of major adverse cardiovascular events, kidney failure or all-cause mortality

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Telomeres are repetitive DNA-protein structures at chromosome ends

Materials and methods Specimen collection After ethical clearance (NReS, Frenchay Hospital, Bristol, UK), disc samples were removed at surgery from 11 patients undergoing spinal fusion for back pain believed to originate from non-herniated discs