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Published by Cambridge University Press on behalf of The Nutrition Society Methotrexate (MTX, 4-amino-N10-methyl folic acid), an antagonist of folic acid, is commonly used as a chemotherapeutic drug to treat a variety of cancers and inflammatory diseases (Reference Puig1)

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[1] Additionally, this review states that there is no convincing evidence from six clinical trials that selenium supplements reduce cancer risk

Elevated homocysteine levels are associated with an increased risk of heart disease