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In the later stages of PD, dopamine agonists may be added to L-dopa therapy in the appropriate patients, providing greater efficacy and reduced motor complications (as compared to L-dopa monotherapy) due to the ability to lower the L-dopa dose
Planta.2004;219:95102.doi:10.1007/s00425-003-1192-3 150
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Most protocols dose by injection close to the site of injury (subcutaneous), though no human pharmacokinetic standard exists
And for some users, the psychological stress of rapid body changes, medication side effects, and health-related decisions creates enough mental activation to interfere with sleep
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