The dosing framework comes from extrapolation: murine studies scaled by body surface area, in vitro keratinocyte studies reverse-engineered to estimate required serum concentration, and anecdotal protocols from research communities using off-label peptides
Nerve problems, such as: numbness or tingling (like muscle weakness)
If you have had Leber's disease (or other forms of optic nerve damage), an iron or folic acid deficiency, or low potassium, your doctor may not recommend it
patients should be well-informed about potential risks and benefits
[1] In practice, 1 mL (which provides the full 100 mg of B and B, etc.) is a common dose for general supplementation in deficient states, but clinicians may start with lower volumes for mild deficiencies or in smaller patients