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F., Carlton, T
These are used as treatment options for type 2 diabetes by helping to control blood sugar levels
Excessive mitochondrial ROS generation can result in H 2 O 2 release from the cell into the circulation as demonstrated by Oshino and Chance using the perfused liver (Oshino et al., 1975)
But given that Novo Nordisk and Eli Lilly have announced their desire to make these blockbuster drugs for their shareholders, and that they are actively working to increase the market for them to be as large as possible, I think it does mean that these drugs should be highly scrutinized and that emphasis should be placed on giving clear, accurate informed consent, including and especially for the larger weight loss doses
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