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Study 3 compared subchronic Cagrilintide treatment in WT and RAMP1/3 double KO mice under HFD conditions

Two-way ANOVA with repeated measures revealed that no significant treatment (F 1, 9 = 0.112, p = NS), no time effect (F 3, 27 = 1.174, p = NS) and no treatment time effect (F 3, 27 = 1.926, p = NS)

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The lack of next-day grogginess that most users report also suggests a cleaner mechanism that does not leave residual effects in the morning

IV therapy bypasses the gut, delivering nearly 100% bioavailability for faster, more noticeable results