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Involvement of tubular sodium in the formation of dopamine in the human renal cortex

The short answer is that it depends heavily on how the supplement is delivered

to date, no clear evidence has been found that it directly induces ROS production, and the amplification effect of related inflammatory damage may need to be mediated through other downstream pathways (114)

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I don't see how you are getting that only 5mcg is lost daily: if you have injected say 1000 mcg of B12, most of it is peed out within a few days