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We confirmed a strong inverse correlation between beta cell mass and glucose intolerance, consistent with clinical observations that OGTT or continuous glucose monitoring (CGM)-derived metrics can predict symptomatic onset in at-risk individuals once beta cell loss has crossed a critical threshold required for metabolic control [66]

Overall, more critical nodes are utilised by GLP-1 suggesting more effective communication between the G protein and the peptide-binding sites, relative to the other peptides, which is consistent with a greater allosteric influence of the G protein on GLP-1 affinity

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Chin Med J (2013) 126:8504

Hormone Panel Subgroup Data The published Phase 2 paper does not include sex-hormone subgroup analyses [1]