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Second, the experimental study duration, while sufficient to detect significant physiological changes, does not provide data on the long-term sustainability of these effects or potential impacts on chronic disease incidence

World J Urol 2015

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It has been described that FGF-2 can promote angiogenesis acting together with VEGF, by inducing the secretion of MMPs, plasminogen activator and collagenase responsible for the degradation and organization of the extracellular matrix [134]