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doi: 10.1186/s12967-020-02277-0 92

Prokineticin is a group of chemokines that promote the release of pro-inflammatory and pro-nociceptive mediators, and are also involved in the epigenetic regulation of genes related to cell differentiation

This article reviews evidence from human clinical trials and animal models, focusing on mechanisms, applications under study, and limitations

In addition to insulin-producing islet cells, the somatostatin-producing islet cells also express GLP1R, whereas glucagon-producing cells appear to lack such receptors