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Because vitamin A is toxic in high doses, taking too much in the form of supplements can be dangerous

Decrease dose consideration: Persistent side effects including headaches, fatigue, or injection site reactions, excessive response (extremely rapid weight loss suggesting dose may be higher than needed), cost concerns when lower doses might achieve similar results

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Certain medical conditions, such as pernicious anemia, may also mean injections are needed

As cells age, mitochondria can become less efficient, leading to a decline in overall cellular function