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Drug-Induced Pancreatitis and Inflammation GLP-1 receptor agonist drugs have also been linked to drug-induced pancreatitis, a painful and sometimes life-threatening inflammation of the pancreas

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Endocr Rev 32:356386 Nordstrom SM, Tran JL, Sos BC, Wagner KU, Weiss EJ (2011) Liver-derived IGF-I contributes to GH-dependent increases in lean mass and bone mineral density in mice with comparable levels of circulating GH

Overstimulation can lead to feedback inhibition , where the hypothalamus and pituitary reduce their natural hormone production