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Conserved domain and motif of protein were analyzed by Pfam, MEME-CHIP, SMART and SCOP online tools [47,48,49,50]

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Immunotherapies, such as immune checkpoint inhibitors (ICIs) (such as cytotoxic T-lymphocyte-associated protein 4 and programmed cell death protein 1/programmed death-ligand 1) have yielded positive results in clinical practice (42)