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Yang PH, et al

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621 In addition, a reduction in amyloid plaque burden has been observed across both the cerebral cortex and hippocampus, although the overall effects on amyloid cascade, neuroinflammation, and behavior are complicated because of the deletion of MT1/2

10.3390/ph11040114 129 ScanzelloC

2.1 Renal Impairment Study 2.1.1 Study Population Male and female participants of non-childbearing potential were eligible for inclusion in the renal impairment study if they were aged between 18 and 80 years with a body mass index (BMI) between 20 and 39.9 kg/m 2 and a body weight 60 kg at screening