This reluctance is likely to be at least partially attributable to the fact that, until recently, all GLP-1RAs were available as subcutaneous (s.c.) injections, given twice daily (exenatide [13]), once daily (lixisenatide [14] and liraglutide [15]), or once weekly (semaglutide [16], dulaglutide [17], and exenatide extended release [18]), a route that may be less preferable to some patients compared with oral administration [1, 19]
Here's the rest of what they found: 1/ Semaglutide periods 42% lower risk of worsening mental illness 44% lower risk of worsening depression 38% lower risk of worsening anxiety 47% lower risk of worsening substance use 2/ This isn't a GLP-1 class effect
Liao K, Su X, Lei K, et al
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