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Activation of Sirtuin has been shown to suppress reactive astrocytes and can thus be used to help treat many forms of neurological disorders like traumatic brain injury and inflammatory neurodegenerative diseases like multiple sclerosis (41)

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For patients and providers, this means tirzepatide may be a better option for those seeking the greatest possible weight reduction or who have not achieved their goals with a GLP-1 agonist alone

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Furthermore, several of the loci identified here overlap or fall near signals reported in prior global glaucoma GWAS, while others may reflect novel ancestry-specific contributions, reinforcing the value of expanding genomic studies in underrepresented populations