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Zhang Y, Taufalele PV, Cochran JD, Robillard-Frayne I, Marx JM, Soto J, et al

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"Key interactions by conserved polar amino acids located at the transmembrane helical boundaries in Class B GPCRs modulate activation, effector specificity and biased signalling in the glucagon-like peptide-1 receptor"

Despite immense progress in comprehending the molecular mechanisms of MDS in the last decade, the available therapeutic options for MDS are limited to transfusions and approved drugs that can only halt or defer the progression of the disease [3]