CNT was calculated using the following formula: multiply drug costs (from an American drug discount website) and follow-up times, then divide by the average percentage of weight loss for each drug in comparison to placebo

The most commonly reported flu-like manifestations include: Nausea and general malaise the most frequent side effect, with incidence varying by product and dose (ranging from approximately 15-40% depending on the specific medication and dosage) Fatigue and low energy levels often described as feeling generally unwell or 'run down' Headaches ranging from mild to moderate intensity Dizziness or light-headedness particularly when standing up quickly, which may reflect dehydration or, in patients also taking insulin or sulfonylureas, possible hypoglycaemia Loss of appetite which, whilst therapeutically beneficial, can contribute to feeling unwell Mild gastrointestinal upset including occasional vomiting or abdominal discomfort These symptoms typically emerge because GLP-1 medications significantly alter gastrointestinal function and metabolic processes
To give a subcutaneous injection : Pinch the skin to make a fold
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doi: 10.1016/j.tcm.2024.03.003 25 PedrosaMRFrancoDRGieremekHWVidalCMBronzeriFde Cassia RochaAet al