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Consequently, the yield was calculated using this purity, 66%, from the concentrations of -EC determined by HPLC analysis using the standard -EC with assumed purity, 100%

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In parallel, advances in NP engineering have enabled therapeutic or diagnostic cargo to be delivered across physiological barriers with high specificity, potentially improving pharmacokinetics, bioavailability, and plasma half-life by shielding payloads from enzymatic degradation and enabling sustained release [16]