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These findings underscore that antibacterial mechanism of GO is largely non-contact-based, driven by oxidative stress rather than mechanical disruption, and that reduction-induced loss of oxygen functionalities impairs its antibacterial potential

They complement each other by improving skin brightness, strengthening the barrier, and reducing pigmentation

The regulation of Ca signaling in astrocytes is primarily mediated by inositol trisphosphate receptors (IP3Rs), which have been studied for their potential roles in brain damage and neuronal death in mouse models 100

Forty-five of these patients developed irAEs, in which 21 patients received steroids