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GLP-1RAs reduce the expression of cholesterol synthesis and bile acid synthesisassociated genes by inhibiting SREBP-2 in HepG2 cells treated with PA To investigate whether SREBP-2 inhibition mediated by GLP-1RAs affects the expression of cholesterol metabolism-related genes, HepG2 cells were transfected with SREBP-2 siRNA for 24 hours, followed by PA and GLP-1RA treatments

Qiu Y, Hther JA, Wank B, Rath A, Tykwe R, Aldrovandi M, et al

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Animals acclimated to the animal room for 3 days should be brought into the laboratory