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Evidence-Based Synthesis: The Latest Data Heres a concise review of the most influential studies: JAMA Ophthalmology (Harvard/Mass Eye & Ear), 20242025: A matched-cohort analysis found higher rates of NAION in patients prescribed semaglutide compared to those on non-GLP-1 medications for diabetes and obesity

In T1DM, autoantibodies show specificity for binding two variants of ZnT8 (R or W at amino acid 325) dictated by a polymorphism in SLC30A8 [43]

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Third, as an observational study, it is difficult to fully control for all potential confounding variables, such as overall diet quality, exercise habits, and comorbidities

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