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Target Engagement Retatrutide engages GLP 1R, GIPR, and GCGR through direct peptide receptor binding that mimics the interaction of endogenous incretin and glucagon peptides

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This view is, however, difficult to reconcile with the extremely rapid degradation of somatostatin in circulation, which makes even a several-fold increase in the local secretion undetectable in the peripheral circulation [4, 5]