[11] Rasburicase is contraindicated in G6PD deficiency
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PMID: 27288086 Abstract Author(s): Toshihiro Kurahashi, Jaeyong Lee, Atsunori Nabeshima, Takujiro Homma, Eun Sil Kang, Yuka Saito, Sohsuke Yamada, Toshiyuki Nakayama, Ken-Ichi Yamada, Satoshi Miyata, Junichi Fujii Abstract: Aldehyde reductase (AKR1A) plays a role in the biosynthesis of ascorbic acid (AsA), and AKR1A-deficient mice produce about 10-15% of the AsA that is produced by wild-type mice
GPX4 converts lipid hydroxy peroxides to corresponding alcohols or free hydrogen peroxide to water together with the reduction of glutathione (GSH) to oxidized glutathione (GSSG) and as such plays an essential role in protecting cells from oxidative stress and ferroptosis [10,11,12]