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Administered as a once-weekly subcutaneous injection, tirzepatide works by enhancing insulin secretion, suppressing glucagon release, and slowing gastric emptying, thereby improving glycaemic control

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Individuals with a history of pancreatitis, medullary thyroid cancer, or severe gastrointestinal disorders should discuss the risks with their provider

Morphine injection significantly induced constipated symptoms in mice, including decreased the output and water content of feces, as well as a reduction in both the transit rate and motility of small intestine (Fig

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