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GIPR agonism inhibits PYY-induced nausea-like behavior

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Key distinction from other GHRPs: Ipamorelin is considered the most selective GHSR agonist, with minimal effects on cortisol release (unlike GHRP-6, GHRP-2), prolactin release, and appetite stimulation (less than ghrelin)

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Lancet Diabetes Endocrinol 10(6):418429