Additionally, GLP1RAs can enhance endothelial nitric oxide synthase (eNOS) activity and NO production by activating the PI3K/Akt and AMPK-eNOS pathways, thereby improving endothelial-dependent vasodilation in diabetic mice and reducing endothelial inflammation and vascular constriction
Kirtleys story is one many South Floridians are telling in exam rooms and waiting areas as prescriptions for GLP1 drugs climb and clinicians and researchers tally both the eyecatching benefits and a new wave of safety questions
Semaglutide Wegovy / Ozempic Mechanism: GLP-1 receptor agonist (single target) Weight loss: ~15-17% body weight (STEP trials, 68 weeks) Dosing: Weekly injection, titrated from 0.25mg to 2.4mg Common side effects: Nausea, vomiting, diarrhea, constipation (typically transient) Availability: Longer track record, more widely available Cardiovascular data: SELECT trial demonstrated 20% reduction in major cardiovascular events Tirzepatide Zepbound / Mounjaro Mechanism: Dual GLP-1 + GIP receptor agonist (two targets) Weight loss: ~20-22% body weight (SURMOUNT trials, 72 weeks) Dosing: Weekly injection, titrated from 2.5mg to 15mg Common side effects: Similar GI profile to semaglutide
10.1016/j.tplants.2004.08.009 9 NoctorG.QuevalG.MhamdiA.ChaouchS.FoyerC
Widely consumed as chimarro , yerba mate is a staple in southern states like Rio Grande do Sul
