Studies demonstrate significant weight loss (10-15% or more with higher doses), reduced cardiovascular events including heart attacks and strokes, potential kidney protection in diabetic patients, reduced fatty liver disease severity, and improvements in metabolic markers including blood pressure and lipids
On the actions of the growth hormone-releasing hexapeptide, GHRP
Tirzepatide (dual GIP + GLP-1 agonist) Tirzepatide targets two pathways (GIP and GLP-1), which is one reason it has shown greater average weight reduction in multiple studies compared with GLP-1-only options
Tirzepatide is a dual agonist (GLP-1 plus GIP), while semaglutide is a GLP-1 single agonist
Clinical features, cardiovascular risk profile, and therapeutic trajectories of patients with type 2 diabetes candidate for oral semaglutide therapy in the Italian specialist care