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PNAS Nexus 2 , pgad403 (2023)

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Once associated with high income countries, this is no longer the case

Approximately 15%30% of Xi-linked genes avoid this silencing, with patterns differing across cellular context, genetic background and developmental stages [108, 109]

One of the interesting findings related to the neurons with TDP-43 pathology is the mitochondrial defects observed at a cellular level 16,17,18