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At this point, there is insufficient evidence to recommend B12 supplementation for fatigue beyond correcting a deficiency

Bibcode:1955Natur.176..325H

People with existing hormonal issues or those undergoing Hormone Therapy should be especially cautious

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Incorporating simple functional assessments, including balance, gait, and coordination tests, into patient evaluations provides a low-cost, early screening tool that can detect dysfunction or deterioration long before cognitive symptoms manifest