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In these patients, when total hepatocyte mass decreases, IGF-I synthesis and glycogen stores decrease (131) resulting in low glucose and intra-portal insulin levels, and a state of hepatic GH resistance ensues

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The molecular weight barrier The 10 kDa threshold is not an arbitrary number

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No differences were observed in pre-load optimization surrogates, with no statistical differences in the left ventricle end-diastolic pressure (LVEDP) (interaction p = 0.60), or in the PPV (interaction, p = 0.30), between groups throughout the experiment (Figure S2)