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46 , 47 Considerable evidence suggests that GLP-1 medicines may reduce the rewarding effects of several addictive substances in rodent models of SUD and in humans, 48 reflecting actions of GLP-1 to modulate the mesolimbic system

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Research summarized by the National Institutes of Health explains that GLP-1 receptor activation also slows gastric emptying and enhances satiety signaling in the brain

After melanin is produced, it is packaged into tiny structures called melanosomes