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In conclusion, AS-IV mitigates cardiac I/R injury through multiple molecular mechanisms, including anti-apoptotic, anti-inflammatory, antioxidant, and mitochondrial protective effects

Science 350 , 11911193 (2015)

A specific role for IGF-1 receptor (IGF-1R) signaling in the mediation of mammalian longevity was first established in IGF-1R haploinsufficient mice, which lived 33% longer than controls, but unlike other models of reduced somatotropic signaling, this effect was female specific 6

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