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This suggests that exposure of insulin to reactive oxidants induces diverse and widespread modifications, potentially contributing to its immunogenicity

Vukovic S, et al

Heres what I believe is happening, based on the medical literature: Collagen Production Slows Down Fibroblasts: the skin cells responsible for making collagen, become less active when exposed to certain metabolic shifts, including the kind triggered by GLP-1s

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Procedures requiring anesthesia Because these medications delay gastric emptying, some anesthesia and procedural guidelines recommend holding GLP-1 medications before procedures to reduce aspiration risk