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Tumor-associated macrophages and fibroblasts may secrete IGF to activate IGF-IR in cancer cells thereby promoting chemoresistance and radioresistance [187, 188]

Amantea D, Marrone MC, Nistic R, Federici M, Bagetta G, Bernardi G, Mercuri NB

Mechanical stress, for instance, can alter chromatin accessibility via histone acetylation or DNA methylation, modulating transcription factors like SOX9 and RUNX2 that direct chondrocyte lineage decisions

(accessed May 2013) 17.Knudsen LB, Nielsen PF, Huusfeldt PO, et al